TOKYO Authentic Trey Lyles Jersey , June 22 (Xinhua) -- Tokyo stocks closed marginally lower Thursday as U.S. equities dropping overnight on falling prices for crude oil saw energy stocks here retreat amid a circumspect market mood.


The 225-issue Nikkei Stock Average edged down 28.28 points, or 0.14 percent, from Wednesday to end the day at 20,110.51.


The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile Authentic Thomas Welsh Jersey , shed 1.18 points, or 0.07 percent, to close at 1,610.38.


Mining, insurance Authentic Richard Jefferson Jersey , and oil and coal product-related issues comprised those that declined the most by the close of play, and advancing issues outpaced declining ones by 992 to 876 on the First Section.


Trading volume on the main section on Thursday came to 1,550.40 million shares, declining from Wednesday's volume of 1,634.36 million shares.


The turnover on the penultimate trading day of the week totaled 2 Authentic Paul Millsap Jersey ,077.1 billion yen (18.70 billion U.S. dollars).


China's J-10B fighter jet to join competition of int'l military game


HKSAR's fifth-term chief executive pledges to serve people with pragmatism


Anti-government protest held in London, Britain


Indonesia's traffic reaches peak before Eid al-Fitr festival


Yoga fans practise yoga across China


Scenery of Zhagana mountains featuring Tibetan-style villages


Snow leopard cubs spotted at headwater region of Yangtze in NW China


In pics: 52nd Int'l Paris Air and Space Show

Lyrica (Pregabalin) is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder. It is effective at treating some causes of chronic pain such as fibromyalgia but not others. It is considered to have a low potential for abuse, and a limited dependence liability if misused.

Mechanism of action:

This drug work by binding to calcium channels found on nerve cells in the brain and spinal cord. This reduces the release of various neurotransmitters from these nerve cells.Neurotransmitters are natural body chemicals that are stored in nerve cells. They are involved in transmitting messages between the nerve cells. Pregabalin is thought to reduce the release of neurotransmitters called glutamate, noradrenaline and substance P.
Glutamate is a neurotransmitter that acts as a natural 'nerve-exciting' agent. It is released when electrical signals build up in nerve cells and subsequently excites more nerve cells. It is thought to play a key role in causing epileptic seizures. Reducing the release of glutamate from the nerve cells in the brain is thought to help stabilize the electrical activity in the brain and prevent epileptic fits.

What is it used for?






Epilepsy - used as an add-on therapy for adults with partial seizures with or without secondary generalization.


Nerve pain (peripheral and central neuropathic pain) in adults, for example due to diabetic neuropathy Authentic Nikola Jokic Jersey , following shingles (post-herpetic neuralgia) or due to spinal cord injury.


Generalized anxiety disorder in adults.



Dosage:



This capsule can be taken either with or without food.


These drugs are usually taken two to three times a day. The dose prescribed depends on the individual, the condition being treated and how well it is controlled.


If you have epilepsy it is important to take your medication regularly, as directed by your doctor, because missing doses can trigger seizures in some people. If you have trouble remembering to take your medicine you should ask your pharmacist for advice. You may find a pill reminder box helpful.


You should not stop taking this medicine suddenly unless your doctor tells you otherwise, as this may result in your seizures Authentic Michael Porter Jersey , nerve pain or anxiety returning or getting worse. If it is decided that you should stop taking this medicine, the dose should usually be reduced gradually over at least a week. Follow the instructions given by your doctor.




Precaution:



This medicine may cause dizziness, sleepiness, confusion or blurred vision and so may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.


This medicine may increase the effects of alcohol.


There may be a small increased risk of suicidal thoughts and behavior in people taking antiepileptic medicines such as pregabalin for any condition. For this reason, it is very important to seek medical advice if you or someone else taking this medicine Authentic Malik Beasley Jersey , experience any changes in mood, distressing thoughts, or feelings about suicide or self-harm at any point while taking this medicine.


This medicine may cause skin reactions. You should let your doctor know if you develop a rash, skin peeling, itching Authentic Jamal Murray Jersey , or other unexplained skin reaction while taking this medicine.


This medicine may sometimes cause allergic reactions, including angioedema. Consult your doctor immediately if you experience difficulty breathing or swallowing, or swelling of your face, lips, tongue or throat while taking this medicine.

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